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KMID : 0366220130480040266
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Korean Journal of Hematology
2013 Volume.48 No. 4 p.266 ~ p.273
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Prognostic value of immunohistochemical algorithms in gastrointestinal diffuse large B-cell lymphoma
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Hwang Hee-Sang
Yoon Dok-Hyun
Suh Cheol-Won
Park Chan-Sik
Huh Joo-Ryung
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Abstract
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Background:
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous clinicopathological entity, and its molecular classification into germinal center B cell-like (GCB) and activated B cell-like (ABC) subtypes using gene expression profile analysis has been shown to have prognostic significance. Recent attempts have been made to find an association between im-munohistochemical findings and molecular subgroup, although the clinical utility of im-munohistochemical classification remains uncertain.
Methods:
The clinicopathological features and follow-up data of 68 cases of surgically resected gas-trointestinal DLBCL were analyzed. Using the immunohistochemical findings on tissue microarray, the cases were categorized into GCB and non-GCB subtypes according to the algorithms proposed by Hans, Muris, Choi, and Tally.
Results:
The median patient age was 56 years (range, 26?77 years). Of the 68 cases included, 39.7% (27/68) involved the stomach, and 60.3% (41/68) involved the intestines. The GCB and non-GCB groups sorted according to Hans, Choi, and Tally algorithms, but not the Muris algorithm, were closely concordant (Hans vs. Choi, κ=0.775, P＜0.001; Hans vs. Tally, κ=0.724, P＜0.001; Choi vs. Tally, κ=0.528, P＜0.001). However, there was no prog-nostic difference between the GCB and non-GCB subtypes, regardless of the algorithm used. On univariate survival analyses, international prognostic index risk group and depth of tumor invasion both had prognostic significance.
Conclusion:
The Hans, Choi, and Tally algorithms might represent identical DLBCL subgroups, but this grouping did not correlate with prognosis. Further studies may delineate the associa-tion between immunohistochemical subgroups and prognosis.
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KEYWORD
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Diffuse large B-cell lymphoma, Gastrointestinal tract, Immunohistochemistry, Prognosis
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